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MINIRIN NASAL SPRAY (DESMOPRESSIN ACETATE): CLINICAL PHARMACOLOGY

Minirin Nasal Spray contains as active substance 1-(3-mercaptopropionic acid)-8-D-arginine vasopressin, which is a synthetic analogue of the natural hormone arginine vasopressin. One ml (0.1 mg) of intranasal desmopressin acetate nasal spray has an antidiuretic activity of about 400 IU; 10 mcg of desmopressin acetate is equivalent to 40 IU.

The change in structure of arginine vasopressin to desmopressin acetate has resulted in a decreased vasopressor action and decreased actions on visceral smooth muscle relative to the enhanced antidiuretic activity, so that clinically effective antidiuretic doses are usually below threshold levels for effects on vascular or visceral smooth muscle.

Minirin Nasal Spray (Desmopressin) administered intranasally has an antidiuretic effect about one-tenth that of an equivalent dose administered by injection.

Pharmacokinetics

Minirin Nasal Spray is absorbed rapidly from the nasal mucosa. Desmopressin Acetate exhibits a biphasic elimination profile, with half-lives of 7.8 and 75.5 minutes for the initial and terminal phases, respectively, in contrast with lysine vasopressin, which has initial and terminal phase half-lives of 2.5 and 14.5 minutes, respectively.

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