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MINIRIN NASAL SPRAY (DESMOPRESSIN ACETATE): DOSAGE AND ADMINISTRATION

Primary Nocturnal Enuresis

Dosage of Minirin (Desmopressin) Nasal Spray should be adjusted according to the individual. The recommended initial dose for those 6 years of age and older is 20 mcg or 0.2 mL solution intranasally at bedtime. Adjustment up to 40 mcg is suggested if the patient does not respond.

Some patients may respond to 10 mcg and adjustment to that lower dose may be done if the patient has shown a response to 20 mcg. It is recommended that one-half of the dose be administered per nostril.

Adequately controlled studies with intranasal Minirin Nasal Spray (Desmopressin) in primary nocturnal enuresis have not been conducted beyond 4-8 weeks.

Central Cranial Diabetes Insipidus

Minirin (Desmopressin) Nasal Spray dosage must be determined for each individual patient and adjusted according to the diurnal pattern of response. Response should be estimated by two parameters: adequate duration of sleep and adequate, not excessive, water turnover. Patients with nasal congestion and blockage have often responded well to intranasal Minirin. The usual dosage range in adults is 0.1 to 0.4 mL daily, either as a single dose or divided into two or three doses. Most adults require 0.2 ml daily in two divided doses. The morning and evening doses should be separately adjusted for an adequate diurnal rhythm of water turnover. For children aged 3 months to 12 years, the usual dosage range is 0.05 to 0.3 ml daily, either as a single dose or divided into two doses. About 1/4 to 1/3 of patients can be controlled by a single daily dose of Minirin administered intranasally.

The nasal spray pump can only deliver doses of 0.1 ml (10 mcg) or multiples of 0.1 mL. If doses other than these are required, the rhinal tube delivery system may be used.

The spray pump must be primed prior to the first use. To prime pump, press down four times. The bottle will now deliver 10 mcg of drug per spray. Discard Minirin (Desmopressin Acetate) spray nasal after 50 sprays since the amount delivered thereafter per spray may be substantially less than 10 mcg of drug.

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